Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma

Targeted therapies to improve tumor immunotherapy.

Durable tumor regression and potential cures of metastatic solid cancers can be achieved by a variety of cellular immunotherapy strategies, including cytokine therapy, dendritic cell-based vaccines, and immune-activating antibodies, when used in so-called immune-sensitive cancers such as melanoma and renal cell carcinoma. However, these immunotherapy strategies have very low tumor response rate...

Small Molecule Drugs and Targeted Therapies for Neuroblastoma

Targeted therapies for killing tumor cells.

I this issue of PNAS, Su et al. (1) present evidence that transfection and expression of the mda-7 gene in human pancreatic cancer cells combined with antisense inhibition of expression of a mutant K-ras gene results in tumor cell growth suppression and induction of apoptosis. They show that both of these treatments are required for this effect and also indicate that these treatments should not...

P11: From Well to Bed: Stem Cell Therapies for Neurotrauma

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EVIDENCE THAT CELL-EXTRACELLULAR MATRIX INTERACTIONS REGULATE DEVELOPMENT AND DIFFERENTIATION Developmental mutations Evidence for the importance of cell-matrix interactions

Differentiation is a continuously regulated process and interactions between the cell and its environment play a major role in maintaining stable expression of differentiation-specific genes (Blau and Baltimore, 1991). An important component of the cellular environment is the extracellular matrix (ECM), which is composed of glycoproteins, proteoglycans and glycosaminoglycans that are secreted a...